Intercellular Adhesion Molecule 3 (ICAM3) antibody

Details for Product No. ABIN6297692
Antigen
  • CD50
  • CDW50
  • ICAM-R
  • ICAM-3
  • ICAM3
  • intercellular adhesion molecule 3
  • ICAM3
  • Icam3
Reactivity
Human
329
5
5
4
2
Host
Mouse
245
82
1
Clonality
Monoclonal
Conjugate
Un-conjugated
19
17
15
7
6
6
3
3
3
3
3
3
3
3
3
3
3
3
3
3
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
204
154
123
83
79
73
63
53
14
11
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4
2
2
1
1
Options
Purpose Mouse anti-Human ICAM-3 Antibody [Sodium Azide Free]
Immunogen Stimulated human leukocytes were used as the immunogen for the ICAM-3 antibody.
Specificity Cell surface
Purification Stimulated human leukocytes were used as the immunogen for the ICAM-3 antibody.
Antigen
Alternative Name Intercellular adhesion molecule 3 (ICAM3 Antibody Abstract)
Background

Target Description: Recognizes an N-glycosylated glycoprotein of 120 kDa with intra-chain disulfide bonds, identified as CD50 or ICAM-3 (WS: IV & V). Its epitope localizes in the D2 extracellular domain and is resistant to neuraminidase and proteases. CD50 is the major ligand for LFA-1 (CD11a/CD18) and may have signalling role to increase adhesion. It is expressed on thymocytes and T lymphocytes and is resistant to treatment with phosphatidylinositol (PI) phospholipase C. This mAb inhibits primary mixed lymphocyte culture (MLC) but not secondary MLC, cytotoxicity or proliferation induced by mitogens. It blocks binding of NK1-L16 stimulated T cells to L cells expressing CD50. This mAb is excellent for staining of formalin/paraffin tissues.

Gene Symbol: ICAM3

Gene ID 3385
UniProt P32942
Application Notes Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Restrictions For Research Use only
Buffer In 1X PBS, BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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