PTH antibody (Parathyroid Hormone)

Details for Product anti-PTH Antibody No. ABIN6297722
Antigen
  • PTH1
  • Pthp
  • PTH-(1-84)
  • Pth1
  • Pthr1
  • PTH
  • parathyroid hormone
  • parathyroid hormone S homeolog
  • PTH
  • Pth
  • pth.S
Reactivity
Human
590
26
15
14
9
9
7
7
5
4
4
3
3
3
Host
Mouse
354
252
44
2
Clonality
Monoclonal
Conjugate
This PTH antibody is un-conjugated
33
22
19
14
14
13
8
7
7
7
7
7
7
7
7
7
7
7
7
7
2
2
2
2
2
2
Application
Immunohistochemistry (IHC)
253
222
214
197
155
102
84
32
27
26
23
22
22
22
3
2
1
Options
Purpose Mouse anti-Human Parathyroid Hormone Antibody [IHC only]
Immunogen Synthetic peptide corresponding to amino acids 1 to 34 of mature PTH was used as the immunogen for the Parathyroid Hormone antibody.
Specificity Cytoplasmic and secreted
Purification Synthetic peptide corresponding to amino acids 1 to 34 of mature PTH was used as the immunogen for the Parathyroid Hormone antibody.
Plasmids, Primers & others Plasmids, Primers & others PTH products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Parathyroid hormone (PTH Antibody Abstract)
Background

Target Description: Epitope of this mAb maps in between aa 1-34. PTH is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH), also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Gene Symbol: PTH

Gene ID 5741
UniProt P01270
Pathways cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process
Application Notes Prediluted format : incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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