Transferrin Receptor (p90, CD71) (TFRC) antibody

Details for Product No. ABIN6297749
Target
Reactivity
Human
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Host
Mouse
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47
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1
Clonality
Monoclonal
Conjugate
Un-conjugated
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11
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2
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Application
Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
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40
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Options
Purpose Mouse anti-Human Transferrin Receptor Antibody [Sodium Azide Free]
Immunogen The KG1 acute myeloid leukemia cell line was used as the immunogen for this Transferrin receptor antibody.
Specificity Cell surface
Purification The KG1 acute myeloid leukemia cell line was used as the immunogen for this Transferrin receptor antibody.
Target
Alternative Name Transferrin receptor protein 1 ] (TFRC Antibody Abstract)
Background

Target Description: This antibody recognizes a ~90-95 kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190 kDa (Workshop IV). The antibody is highly specific to transferrin receptor and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.

Gene Symbol: TFRC
Gene ID 7037
UniProt P02786
Pathways Transition Metal Ion Homeostasis
Application Notes FACS: 0.5-1 μg/million cells
IF: 1-2 μg/mL
WB: 0.25-0.5 μg/mL
Restrictions For Research Use only
Buffer In 1X PBS ( pH 7.4), BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.