Transferrin Receptor (p90, CD71) (TFRC) (AA 608-727) antibody

Details for Product No. ABIN1724899
Antigen
Epitope
AA 608-727
47
28
26
14
11
11
8
7
5
4
4
4
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Monkey, Rat (Rattus)
575
165
46
10
6
6
5
5
5
4
3
2
1
1
Host
Mouse
450
156
108
7
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
73
63
62
30
8
7
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
4
4
4
4
3
3
2
2
2
2
2
2
2
2
1
Application
ELISA, Western Blotting (WB)
483
280
187
175
141
110
57
45
42
26
12
8
8
6
2
2
2
1
1
1
1
Options
Immunogen Purified recombinant fragment of human TFRC (AA 608-727) expressed in E. Coli.
Clone 1A1B2
Isotype IgG1
Purification Purified
Antigen
Alternative Name TFRC (TFRC Antibody Abstract)
Background Transferrin receptor is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. Low iron concentrations promote increased levels of transferrin receptor, to increase iron intake into the cell. Thus, transferrin receptor maintains cellular iron homeostasis. Expression of human TFR1, but not human TFR2, in hamster cell lines markedly enhanced the infection of viruses pseudotyped with the glycoprotein of Machupo, Guanarito, and Junin viruses, but not with those of Lassa or lymphocytic choriomeningitis viruses. An anti-TFR1 antibody efficiently inhibited the replication of Machupo, Guanarito, Junin, and Sabia viruses, but not that of Lassa virus.TFR1 is a cellular receptor for New World hemorrhagic fever arenaviruses. , ,
Molecular Weight 85 kDa
Gene ID 7037
HGNC 7037
Pathways Transition Metal Ion Homeostasis
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-Transferrin Receptor (p90, CD71) (TFRC) (AA 608-727) antibody (ABIN1724899) anti-Transferrin Receptor (p90, CD71) (TFRC) (AA 608-727) antibody (Image 1)
Image no. 2 for anti-Transferrin Receptor (p90, CD71) (TFRC) (AA 608-727) antibody (ABIN1724899) anti-Transferrin Receptor (p90, CD71) (TFRC) (AA 608-727) antibody (Image 2)
Image no. 3 for anti-Transferrin Receptor (p90, CD71) (TFRC) (AA 608-727) antibody (ABIN1724899) anti-Transferrin Receptor (p90, CD71) (TFRC) (AA 608-727) antibody (Image 3)
Image no. 4 for anti-Transferrin Receptor (p90, CD71) (TFRC) (AA 608-727) antibody (ABIN1724899) anti-Transferrin Receptor (p90, CD71) (TFRC) (AA 608-727) antibody (Image 4)
Product cited in: Płoszyńska, Ruckemann-Dziurdzińska, Jóźwik, Mikosik, Lisowska, Balcerska, Witkowski: "Cytometric evaluation of transferrin receptor 1 (CD71) in childhood acute lymphoblastic leukemia." in: Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society, Vol. 50, Issue 2, pp. 304-11, 2012 (PubMed).

Jian, Yang, Huang: "Src regulates Tyr(20) phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival." in: The Journal of biological chemistry, Vol. 286, Issue 41, pp. 35708-15, 2011 (PubMed).