Neurofilament, Heavy Polypeptide (NEFH) antibody

Details for Product No. ABIN6297788
Antigen
  • NF-H
  • NF200
  • Nfh
  • mKIAA0845
  • NFH
  • NEFH
  • neurofilament heavy polypeptide
  • neurofilament, heavy polypeptide
  • neurofilament heavy
  • MCYG_06231
  • Nefh
  • NEFH
Reactivity
Chicken, Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
266
200
180
123
121
61
23
23
19
18
18
16
13
9
9
7
3
2
2
1
1
Host
Mouse
215
97
21
Clonality
Monoclonal
Conjugate
Un-conjugated
6
6
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (IHC)
189
143
88
80
62
55
45
43
32
14
14
10
7
6
2
2
2
1
1
Options
Purpose Mouse anti-Human/Mouse/Rat/Chicken/Pig Neurofilament Heavy Antibody [Sodium Azide Free]
Immunogen The triton-X 100 insoluble protein fraction of rat brain was used as the immunogen for this Neurofilament Heavy antibody.
Specificity Cytoplasmic
Purification The triton-X 100 insoluble protein fraction of rat brain was used as the immunogen for this Neurofilament Heavy antibody.
Antigen
Alternative Name Neurofilament heavy polypeptide (NEFH Antibody Abstract)
Background

Target Description: This antibody reacts with a 200 kDa protein, identified as heavy subunit of neurofilaments, or NF-H. Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68 kDa (NF-L), 160 kDa (NF-M) and 200 kDa (NF-H), plus alpha internexin or peripherin. Each neurofilament subunit contains a globular head, an alpha helical rod domain, and variable tail domains that differ in length and amino acid content.Neurofilament antibody stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for neurofilament antibody. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and cell carcinomas of the lung also express neurofilament.

Gene Symbol: NEFH///KIAA0845///NFH

Gene ID 4744
UniProt P12036
Application Notes FACS: 0.5-1 μg/million cells
IHC (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer In 1X PBS ( pH 7.4), BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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