PGC antibody (Biotin)

Catalog No. ABIN6297821

Product Details anti-PGC Antibody (Biotin)

Target: PGC (Pepsinogen C (PGC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PGC antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA

Purpose: Mouse anti-Human PGC Biotinylated Antibody

Immunogen: This antibody was produced by fusion of mouse myeloma with B cells obtained from a mouse immunized with a recombinant protein immunogen. The IgG fraction of tissue culture supernatant was purified by Protein G/A affinity chromatography.

Clone: 4H4-E9-E4

Isotype: IgG1

Application Details

Application Notes: ELISA (recommended dilution= 1:320,000), Western Blotting (recommended dilution= 1:1,000-5,000)

Restrictions: For Research Use only

Handling

Reconstitution: A separate vial of dilution buffer is provided for reconstitution. The antibody is supplied lyophilized, originally containing PBS, without preservative stabilizers (e. g. sodium azide). The final amount is indicated on the shipping vial.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: -20°C

Target Details for PGC

Target: PGC (Pepsinogen C (PGC))

Alternative Name: PGC (PGC Products)

Synonyms: PEPC antibody, PGII antibody, 2210410L06Rik antibody, Upg-1 antibody, Upg1 antibody, CPGC antibody, gastricsin antibody, PG1 antibody, Pg-1 antibody, PGNC antibody, PGC antibody, Gastricsin antibody, progastricsin (pepsinogen C) antibody, progastricsin antibody, PGC antibody, Pgc antibody

Background:

Target Description: PGC gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.

UniProt: P20142