Kininogen 1 (KNG1) antibody (Biotin)

Details for Product No. ABIN6297826
Antigen
  • BDK
  • BK
  • KNG
  • Kng
  • KNG2
  • fb64g01
  • wu:fb64g01
  • zgc:103569
  • kininogen
  • bdk
  • kng
  • KNG1
  • IHRP
  • KINKG
  • KINKH
  • Kng1
  • Kngk
  • kininogen 1
  • kininogen 1 L homeolog
  • inter-alpha-trypsin inhibitor heavy chain family member 4
  • kininogen 2-like 1
  • KNG1
  • Kng1
  • kng1
  • kng1.L
  • ITIH4
  • Kng2l1
Reactivity
Human
150
27
24
4
2
2
2
1
1
1
1
1
Host
Rabbit
144
22
18
1
Clonality
Polyclonal
Conjugate
Biotin
14
10
9
4
4
4
4
2
2
2
2
2
Application
ELISA, Western Blotting (WB)
133
97
69
20
19
18
14
10
8
5
5
3
2
2
1
1
1
Options
Purpose Rabbit anti-Human Bradykinin [+Biotin] Antibody,
Immunogen This antibody was produced from antiserum of rabbits immunized with a polypeptide immunogen. The IgG fraction was purified by Protein G/A affinity chromatography.
Isotype IgG
Antigen
Alternative Name Kininogen-1 , Kininogen-1 light chain, Low molecular weight growth-promoting factor] (KNG1 Antibody Abstract)
Background

Target Description: Bradykinin is a potent endothelium-dependent vasodilator, leading to a drop in blood pressure. It also causes contraction of non-vascular smooth muscle in the bronchus and gut, increases vascular permeability and is also involved in the mechanism of pain.Bradykinin also causes natriuresis, contributing to the drop in blood pressure.Bradykinin raises internal calcium levels in neocortical astrocytes causing them to release glutamate.Bradykinin is also thought to be the cause of the dry cough in some patients on angiotensin-converting enzyme (ACE) inhibitor drugs. It is thought that bradykinin is converted to inactive metabolites by ACE, therefore inhibition of this enzyme leads to increased levels of bradykinin, which causes a dry cough via bronchoconstriction. This refractory cough is a common cause for stopping ACE inhibitor therapy, in which case angiotensin II receptor antagonists (ARBs) are the next line of treatment.Overactivation of bradykinin is thought to play a role in a rare disease called hereditary angioedema, formerly known as hereditary angio-neurotic edema.

Gene Symbol: KNG1///BDK///KNG

Gene ID 3827
UniProt P01042
Pathways ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process
Application Notes ELISA (recommended work dilution= 1:16,000), Western Blotting (recommended work dilution= 1:1,000-5,002),
Restrictions For Research Use only
Reconstitution Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile 1 x PBS to a final concentration of 1 mg/mL.
Storage 4 °C,-20 °C,-80 °C
Storage Comment -20°C
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