KNG1 antibody (Biotin)
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- Target See all KNG1 Antibodies
- KNG1 (Kininogen 1 (KNG1))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This KNG1 antibody is conjugated to Biotin
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Application
- Western Blotting (WB), ELISA
- Purpose
- Rabbit anti-Human Bradykinin [+Biotin] Antibody,
- Immunogen
- This antibody was produced from antiserum of rabbits immunized with a polypeptide immunogen. The IgG fraction was purified by Protein G/A affinity chromatography.
- Isotype
- IgG
- Top Product
- Discover our top product KNG1 Primary Antibody
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- Application Notes
- ELISA (recommended work dilution= 1:16,000), Western Blotting (recommended work dilution= 1:1,000-5,002),
- Restrictions
- For Research Use only
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- Reconstitution
- Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile 1 x PBS to a final concentration of 1 mg/mL.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- -20°C
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- Target
- KNG1 (Kininogen 1 (KNG1))
- Alternative Name
- Kininogen-1 , Kininogen-1 light chain, Low molecular weight growth-promoting factor] (KNG1 Products)
- Synonyms
- BDK antibody, BK antibody, KNG antibody, Kng antibody, KNG2 antibody, fb64g01 antibody, wu:fb64g01 antibody, zgc:103569 antibody, kininogen antibody, bdk antibody, kng antibody, KNG1 antibody, IHRP antibody, KINKG antibody, KINKH antibody, Kng1 antibody, Kngk antibody, kininogen 1 antibody, kininogen 1 L homeolog antibody, inter-alpha-trypsin inhibitor heavy chain family member 4 antibody, kininogen 2-like 1 antibody, KNG1 antibody, Kng1 antibody, kng1 antibody, kng1.L antibody, ITIH4 antibody, Kng2l1 antibody
- Background
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Target Description: Bradykinin is a potent endothelium-dependent vasodilator, leading to a drop in blood pressure. It also causes contraction of non-vascular smooth muscle in the bronchus and gut, increases vascular permeability and is also involved in the mechanism of pain.Bradykinin also causes natriuresis, contributing to the drop in blood pressure.Bradykinin raises internal calcium levels in neocortical astrocytes causing them to release glutamate.Bradykinin is also thought to be the cause of the dry cough in some patients on angiotensin-converting enzyme (ACE) inhibitor drugs. It is thought that bradykinin is converted to inactive metabolites by ACE, therefore inhibition of this enzyme leads to increased levels of bradykinin, which causes a dry cough via bronchoconstriction. This refractory cough is a common cause for stopping ACE inhibitor therapy, in which case angiotensin II receptor antagonists (ARBs) are the next line of treatment.Overactivation of bradykinin is thought to play a role in a rare disease called hereditary angioedema, formerly known as hereditary angio-neurotic edema.
Gene Symbol: KNG1///BDK///KNG
- Gene ID
- 3827
- UniProt
- P01042
- Pathways
- ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process
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