USP5 antibody

Catalog No. ABIN6297889

Product Details anti-USP5 Antibody

Target: USP5 (Ubiquitin Specific Peptidase 5 (USP5))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This USP5 antibody is un-conjugated

Application: Please inquire

Purpose: Mouse Anti-USP5 Antibody

Immunogen: This USP5 antibody is generated from a mouse immunized with a recombination protein from the human region of human USP5.

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for USP5

Target: USP5 (Ubiquitin Specific Peptidase 5 (USP5))

Alternative Name: USP5 (USP5 Products)

Background:

Target Description: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

Gene Symbol: USP5

Gene ID: 8078

UniProt: P45974