Valosin Containing Protein (vcp) antibody

Details for Product No. ABIN6297890
Antigen
  • ALS14
  • IBMPFD
  • TERA
  • p97
  • CDC48
  • wu:fd16d05
  • wu:fj63d11
  • p93
  • 3110001E05
  • p97/VCP
  • 22.26
  • 7.12
  • Apple
  • BcDNA.GM02885
  • BcDNA:GM02885
  • CG2331
  • DmTER94
  • Dmel\CG2331
  • I
  • Ter94
  • Tera
  • VCP
  • VCP ATPase
  • VCP/p97
  • Vcp
  • anon-WO2004063362.65
  • anon-WO2004063362.67
  • cdc48
  • dTERA
  • dVCP
  • dmTERA
  • dvcp
  • l(2)03775
  • l(2)46CFf
  • l(2)46CFs
  • l(2)46Ch
  • pTER94
  • ter94
  • vcp
  • FANCG
  • valosin containing protein
  • valosin containing protein S homeolog
  • valosin-containing protein
  • CG2331 gene product from transcript CG2331-RA
  • transitional endoplasmic reticulum ATPase
  • VCP
  • vcp.S
  • vcp
  • Vcp
  • Bm1_56585
  • LOC100136246
  • TER94
  • LOC101109680
Reactivity
Human, Mouse (Murine), Rat (Rattus)
159
84
78
15
9
8
8
6
6
4
4
3
3
2
1
1
1
1
1
1
Host
Mouse
122
44
2
Clonality
Monoclonal
Conjugate
Un-conjugated
6
6
3
3
3
3
3
3
3
2
2
2
Application
148
67
55
32
25
22
17
16
10
8
3
2
2
1
1
Options
Purpose Mouse Anti-VCP Antibody
Immunogen This VCP antibody is generated from a mouse immunized with a recombinant protein from human VCP.
Antigen
Alternative Name VCP (vcp Antibody Abstract)
Background

Target Description: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168- dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.

Gene Symbol: VCP

Gene ID 7415
UniProt P55072
Pathways ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity
Restrictions For Research Use only
Storage 4 °C,-20 °C
Storage Comment 2-8°C (short-term), -20°C (long-term)
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