Cyclin D2 antibody (CCND2)

Details for Product anti-CCND2 Antibody No. ABIN6298006
Antigen
  • si:ch211-240j22.2
  • ccnd2
  • CCND2
  • kiak0002
  • zgc:162280
  • LOC100224096
  • KIAK0002
  • BF642806
  • C86853
  • Vin-1
  • Vin1
  • cD2
  • 2600016F06Rik
  • AI256817
  • cyclin D2, b
  • cyclin D2 S homeolog
  • cyclin D2
  • G1/S-specific cyclin-D2
  • cyclin D2, a
  • cyclin D2 L homeolog
  • ccnd2b
  • ccnd2.S
  • CCND2
  • ccnd2
  • ccnd2a
  • Ccnd2
  • ccnd2.L
Reactivity
Human, Mouse (Murine), Rat (Rattus)
226
105
81
1
1
1
1
1
1
1
Host
Rabbit
173
61
Clonality
Polyclonal
Conjugate
This Cyclin D2 antibody is un-conjugated
9
5
5
5
5
5
5
5
5
4
3
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
179
66
63
29
26
15
13
13
13
10
7
6
2
2
2
2
1
1
Options
Purpose Rabbit Anti-Cyclin D2 (Ab-280) Antibody,
Plasmids, Primers & others Plasmids, Primers & others Cyclin D2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Cyclin D2 (CCND2 Antibody Abstract)
Background

Target Description: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Gene Symbol: CCND2

Gene ID 894
UniProt P30279
Pathways Cell Division Cycle, Mitotic G1-G1/S Phases
Restrictions For Research Use only
Storage 4 °C,-20 °C
Storage Comment 2-8°C (short-term), -20°C (long-term)