CD40 antibody (CD40 Molecule, TNF Receptor Superfamily Member 5)

Details for Product anti-CD40 Antibody No. ABIN6566508
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
465
233
68
16
16
9
9
6
4
3
3
2
2
2
1
1
Host
Rabbit
322
184
131
12
1
Clonality
Polyclonal
Conjugate
This CD40 antibody is un-conjugated
66
66
39
26
10
9
8
5
5
4
4
4
4
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
382
196
159
107
78
55
52
47
35
14
13
12
5
4
3
3
2
2
2
1
1
1
1
1
1
1
Options
Immunogen Recombinant protein of human CD40
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name CD40 (CD40 Antibody Abstract)
Background

Synonyms: AI326936,B cell associated molecule CD40,B cell surface antigen CD40,B cell-associated molecule,B-cell surface antigen CD40,Bp50,CD 40,CD40,CD40 antigen (TNF receptor superfamily member 5),CD40 antigen,CD40 Molecule,CD40 Molecule,TNF receptor superfamily member 5,CD40 protein,CD40 type II isoform,CD40L receptor,CDw40,GP39,HIGM1,IGM,IMD3,MGC9013,Nerve growth factor receptor related B lymphocyte activation molecule,OTTHUMP00000031699,OTTHUMP00000031700,p50,T-BAM,TBAM,TNF receptor superfamily member 5,TNFRSF5,TNR5,TRAP,Tumor necrosis factor receptor superfamily,member 5,Tumor necrosis factor receptor superfamily member 5,Tumor necrosis factor receptor superfamily member 5 precursor,Tumor necrosis factor receptor superfamily,member 5,isoform CRA_a

Background: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Molecular Weight

Observed_MW: 42kDa

Calculated_MW: 22kDa/30kDa

Gene ID 958
UniProt P25942
Pathways NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
Application Notes WB 1:500 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) antibody (ABIN6566508) Western blot analysis of extracts of various cell lines, using CD40 Antibody.