FASL antibody (Fas Ligand (TNF Superfamily, Member 6))

Details for Product anti-FASL Antibody No. ABIN6566520
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
259
104
65
5
4
3
3
2
1
1
Host
Rabbit
166
93
32
20
8
1
Clonality
Polyclonal
Conjugate
This FASL antibody is un-conjugated
25
18
15
5
5
4
3
3
3
3
3
2
2
1
1
1
1
1
Application
Western Blotting (WB)
173
125
82
72
53
35
26
20
20
13
11
9
7
7
5
2
1
1
1
1
1
1
1
Options
Immunogen A synthetic peptide of human FASLG
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name FASLG (FASL Antibody Abstract)
Background

Synonyms: ALPS1B,Apoptosis (APO 1) antigen ligand 1,Apoptosis antigen ligand 1,Apoptosis antigen ligand,APT1LG1,APTL,CD178,CD178 antigen,CD95 ligand,CD95-L,CD95L,CD95L protein,Fas antigen ligand,Fas L,Fas ligand (TNF superfamily member 6),Fas ligand,FASL,Fasl Fas ligand (TNF superfamily member 6),FASLG,Generalized lymphoproliferative disease,Gld,soluble form,TNFL6,TNFSF6,Tumor necrosis factor (ligand) superfamily member 6,Tumor necrosis factor ligand superfamily member 6

Background: This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described.

Molecular Weight

Observed_MW: 45kDa

Calculated_MW: 14kDa/31kDa

Gene ID 356
UniProt P48023
Pathways Apoptosis, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
Application Notes WB 1:500 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) antibody (ABIN6566520) Western blot analysis of extracts of various cell lines, using FASLG antibody.