Synonyms: Amphiregulin associated protein,Amphiregulin-associated protein,ARAP,FLJ27379,Mdk,Midgestation and kidney protein,Midkine,MK 1,MK,MK,MK1,NEGF 2,NEGF2,Neurite growth promoting factor 2,Neurite outgrowth promoting protein,Neurite outgrowth-promoting factor 2,Neurite outgrowth-promoting protein,Retinoic acid inducible factor
Background: This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed.