FGFR3 antibody (Fibroblast Growth Factor Receptor 3)

Details for Product anti-FGFR3 Antibody No. ABIN6566588
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
165
78
60
6
2
2
2
1
Host
Rabbit
161
11
1
Clonality
Polyclonal
Conjugate
This FGFR3 antibody is un-conjugated
15
10
8
6
6
6
6
6
6
4
4
4
1
1
1
1
1
Application
Western Blotting (WB)
115
84
77
21
13
10
9
7
3
3
2
1
1
1
1
1
Options
Immunogen Recombinant protein of human FGFR3
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name FGFR3 (FGFR3 Antibody Abstract)
Background

Synonyms: ACH,CD 333,CD333,CD333 antigen,CEK 2,CEK2,FGFR 3,FGFR-3,FGFR3,FGFR3,Fibroblast growth factor receptor 3 (achondroplasia thanatophoric dwarfism),Fibroblast growth factor receptor 3,Heparin binding growth factor receptor,HSFGFR3EX,Hydroxyaryl protein kinase,JTK 4,JTK4,MFR 3,SAM 3,Tyrosine kinase JTK 4,Tyrosine kinase JTK4,Z FGFR 3

Background: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Molecular Weight

Observed_MW: 115kDa

Calculated_MW: 75kDa/85kDa/87kDa/88kDa

Gene ID 2261
UniProt P22607
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding
Application Notes WB 1:500 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Fibroblast Growth Factor Receptor 3 (FGFR3) antibody (ABIN6566588) Western blot analysis of extracts of various cell lines, using FGFR3 antibody.