DYRK1A antibody

Catalog No. ABIN6566622

Product Details anti-DYRK1A Antibody

Target: DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYRK1A antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human DYRK1A

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DYRK1A

Target: DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))

Alternative Name: DYRK1A (DYRK1A Products)

Background:

Synonyms: Dual specificity tyrosine phosphorylation regulated kinase,Dual specificity tyrosine (Y) phosphorylation regulated kinase 1A,Dual specificity tyrosine phosphorylation regulated kinase 1,Dual specificity tyrosine phosphorylation regulated kinase 1A,Dual specificity tyrosine-phosphorylation-regulated kinase 1A,Dual specificity YAK 1 related kinase,Dual specificity YAK1 related kinase,Dual specificity YAK1-related kinase,DYR1A,DYRK 1,DYRK 1A,DYRK,DYRK1,Dyrk1a,DYRKA,hMNB,HP 86,HP86,Minibrain (Drosophila) homolog,Minibrain homolog,Minibrain,Drosophila,homolog of,MNB,MNB protein kinase,Mnb protein kinase homolog hp86,MNB protein kinase,Serine/threonine-specific,MNB/DYRK protein kinase,MNBH,MRD7,OTTHUMP00000109090,OTTHUMP00000109091,OTTHUMP00000109094,OTTHUMP00000174799,Protein kinase minibrain homolog,Serine/threonine kinase MNB

Background: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

Molecular Weight:

Observed_MW: 72kDa

Calculated_MW: 60kDa/61kDa/66kDa/84kDa/85kDa

Gene ID: 1859

UniProt: Q13627

Pathways: Mitotic G1-G1/S Phases