DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A)

Details for Product anti-DYRK1A Antibody No. ABIN6566622
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
124
57
48
8
5
5
5
5
4
3
2
2
2
1
Host
Rabbit
113
7
6
3
Clonality
Polyclonal
Conjugate
This DYRK1A antibody is un-conjugated
9
9
8
7
7
7
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
117
75
20
15
13
10
9
7
5
4
2
2
Options
Immunogen Recombinant protein of human DYRK1A
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name DYRK1A (DYRK1A Antibody Abstract)
Background

Synonyms: Dual specificity tyrosine phosphorylation regulated kinase,Dual specificity tyrosine (Y) phosphorylation regulated kinase 1A,Dual specificity tyrosine phosphorylation regulated kinase 1,Dual specificity tyrosine phosphorylation regulated kinase 1A,Dual specificity tyrosine-phosphorylation-regulated kinase 1A,Dual specificity YAK 1 related kinase,Dual specificity YAK1 related kinase,Dual specificity YAK1-related kinase,DYR1A,DYRK 1,DYRK 1A,DYRK,DYRK1,Dyrk1a,DYRKA,hMNB,HP 86,HP86,Minibrain (Drosophila) homolog,Minibrain homolog,Minibrain,Drosophila,homolog of,MNB,MNB protein kinase,Mnb protein kinase homolog hp86,MNB protein kinase,Serine/threonine-specific,MNB/DYRK protein kinase,MNBH,MRD7,OTTHUMP00000109090,OTTHUMP00000109091,OTTHUMP00000109094,OTTHUMP00000174799,Protein kinase minibrain homolog,Serine/threonine kinase MNB

Background: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

Molecular Weight

Observed_MW: 72kDa

Calculated_MW: 60kDa/61kDa/66kDa/84kDa/85kDa

Gene ID 1859
UniProt Q13627
Pathways Mitotic G1-G1/S Phases
Application Notes WB 1:500 - 1:1000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) antibody (ABIN6566622) Western blot analysis of extracts of various cell lines, using DYRK1A antibody.