Synonyms: Acidic fibroblast growth factor,aFGF,Beta endothelial cell growth factor,Beta-endothelial cell growth factor,ECGF,ECGF beta,ECGF-beta,ECGFA,ECGFB,Endothelial Cell Growth Factor alpha,Endothelial Cell Growth Factor beta,FGF 1,FGF alpha,Fgf1,FGF1,FGFA,Fibroblast Growth Factor 1 Acidic,Fibroblast growth factor 1,GLIO703,HBGF 1,HBGF-1,HBGF1,Heparin binding growth factor 1,Heparin binding growth factor 1 precursor,Heparin-binding growth factor 1
Background: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.