Synonyms: 1810013K23Rik,Apg 7,APG7 autophagy 7 like,APG7 autophagy 7-like (S. cerevisiae),APG7 like,APG7,S. cerevisiae,homolog of,APG7-like,APG7L,ATG 7,ATG12-activating enzyme E1 ATG7,ATG7,ATG7 autophagy related 7 homolog (S. cerevisiae),ATG7 autophagy related 7 homolog,ATG7,Atg7l,Autophagy 7,S. cerevisiae,homolog of,Autophagy related protein 7,Autophagy-related 7 (yeast),Autophagy-related protein 7,DKFZp434N0735,GSA 7,GSA7,hAGP7,Ubiquitin activating enzyme E1 like protein,Ubiquitin-activating enzyme E1-like protein,Ubiquitin-like modifier-activating enzyme ATG7
Background: This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants.