ADAM17 antibody (ADAM Metallopeptidase Domain 17)

Details for Product anti-ADAM17 Antibody No. ABIN6566679
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
221
89
81
1
Host
Rabbit
197
21
7
2
1
Clonality
Polyclonal
Conjugate
This ADAM17 antibody is un-conjugated
14
10
7
6
6
5
4
4
4
4
4
4
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
176
106
43
37
23
14
13
10
7
6
3
3
2
2
1
Options
Immunogen A synthetic peptide of human ADAM17
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name ADAM17 (ADAM17 Antibody Abstract)
Background

Synonyms: A disintegrin and metalloproteinase domain 17 (tumor necrosis factor,alpha,converting enzyme),A disintegrin and metalloproteinase domain 17,ADA17,ADAM 17,ADAM metallopeptidase domain 17,ADAM17,ADAM17 protein,CD 156b,CD156b,CD156b antigen,CSVP,Disintegrin and metalloproteinase domain-containing protein 17,MGC71942,NISBD,NISBD1,Snake venom like protease,Snake venom-like protease,TACE,TNF alpha convertase,TNF alpha converting enzyme,TNF-alpha convertase,TNF-alpha-converting enzyme,Tumor Necrosis Factor Alpha Converting Enzyme

Background: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.

Molecular Weight

Observed_MW: 115kDa

Calculated_MW: 78kDa/93kDa

Gene ID 6868
UniProt P78536
Pathways Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
Application Notes WB 1:500 - 1:2000 IHC 1:100 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-ADAM Metallopeptidase Domain 17 (ADAM17) antibody (ABIN6566679) Western blot analysis of extracts of various cell lines, using ADAM17 antibody.
Image no. 2 for anti-ADAM Metallopeptidase Domain 17 (ADAM17) antibody (ABIN6566679) Immunohistochemistry of paraffin-embedded rat heart using ADAM17 antibody.