SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) antibody

Details for Product No. ABIN6566687
Antigen
Reactivity
Human
129
84
66
3
2
2
2
Host
Rabbit
97
25
4
4
Clonality
Polyclonal
Conjugate
Un-conjugated
6
4
4
4
4
4
4
2
1
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
98
42
37
23
16
13
6
4
4
3
3
2
2
1
Options
Immunogen A synthetic peptide of human SMARCA4
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name SMARCA4 (SMARCA4 Antibody Abstract)
Background

Synonyms: ATP dependent helicase SMARCA4,ATP-dependent helicase SMARCA4,BAF 190,BAF190,BAF190A,Brahma protein like 1,BRG1,BRG1 associated factor 190A,BRG1 protein,BRG1-associated factor 190A,BRM/SWI2 related gene 1,Global transcription activator homologous sequence,global transcription activator snf2l4,Homeotic gene regulator,hSNF2b,Mitotic growth and transcription activator,MRD16,Nuclear protein GRB1,Protein brahma homolog 1,Protein BRG-1,Protein BRG1,RTPS2,SMARC A4,SMARCA4,SMCA4,SNF2,SNF2 beta,SNF2 like 4,SNF2-beta,SNF2B,SNF2L4,SNF2LB,Sucrose nonfermenting like 4,SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 4,SWI/SNF related,matrix associated,actin dependent regulator of chromatin,subfamily a,member 4,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4,SWI2,Transcription activator BRG1

Background: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight

Observed_MW: 180kDa

Calculated_MW: 181kDa/184kDa

Gene ID 6597
UniProt P51532
Pathways Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Stem Cell Maintenance
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:20 - 1:50
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) antibody (ABIN6566687) Immunofluorescence analysis of HeLa cells using SMARCA4 antibody.
Image no. 2 for anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) antibody (ABIN6566687) Immunohistochemistry of paraffin-embedded human colon using SMARCA4 antibody.
Image no. 3 for anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) antibody (ABIN6566687) Immunohistochemistry of paraffin-embedded human colon carcinoma using SMARCA4 antibody.
Image no. 4 for anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) antibody (ABIN6566687) Western blot analysis of extracts of various cell lines, using SMARCA4 antibody.