TRAF2 antibody (TNF Receptor-Associated Factor 2)

Details for Product anti-TRAF2 Antibody No. ABIN6566707
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
188
74
69
2
1
1
1
1
1
1
Host
Rabbit
140
43
8
1
Clonality
Polyclonal
Conjugate
This TRAF2 antibody is un-conjugated
10
7
7
5
5
5
4
4
4
4
4
4
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
156
75
68
32
24
19
14
13
10
7
4
4
3
3
3
Options
Immunogen Recombinant protein of human TRAF2
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name TRAF2 (TRAF2 Antibody Abstract)
Background

Synonyms: E3 ubiquitin-protein ligase TRAF2,MGC:45012,OTTHUMP00000022625,OTTHUMP00000064745,TNF receptor associated factor 2,TNF receptor-associated factor 2,TNF receptor-associated protein,TRAF 2,TRAF2,TRAF2,TRAP 3,TRAP,TRAP3,Tumor necrosis factor type 2 receptor associated protein 3,Tumor necrosis factor type 2 receptor-associated protein 3

Background: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

Molecular Weight

Observed_MW: 54kDa

Calculated_MW: 53kDa/54kDa/55kDa/61kDa

Gene ID 7186
UniProt Q12933
Pathways NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded protein response
Application Notes WB 1:500 - 1:2000 IF 1:20 - 1:100
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-TNF Receptor-Associated Factor 2 (TRAF2) antibody (ABIN6566707) Western blot analysis of extracts of various cell lines, using TRAF2 antibody.
Image no. 2 for anti-TNF Receptor-Associated Factor 2 (TRAF2) antibody (ABIN6566707) Immunofluorescence analysis of HeLa cells using TRAF2 antibody.