Synonyms: 94 kDa glucose regulated protein,94 kDa glucose-regulated protein,ECGP,Endoplasmin,Endothelial cell (HBMEC) glycoprotein,ENPL,Glucose regulated protein 94 kDa,gp96,gp96 homolog,GRP 94,GRP-94,Heat shock protein 90 kDa beta member 1,heat shock protein 90 kDa beta (Grp94),member 1,Heat shock protein,90 kDa,beta,1,HSP90B1,Stress inducible tumor rejection antigen GP96,TRA1,tumor rejection antigen (gp96) 1,Tumor rejection antigen 1,Tumor rejection antigen gp96,Tumor rejection antigen-1 (gp96)
Background: This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15.