Desmocollin 1 antibody (DSC1)

Details for Product anti-DSC1 Antibody No. ABIN6566762
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
46
11
3
Host
Rabbit
43
8
1
Clonality
Polyclonal
Conjugate
This Desmocollin 1 antibody is un-conjugated
3
2
2
2
2
2
1
1
1
1
1
1
Application
Western Blotting (WB)
40
25
21
7
6
4
4
2
2
2
1
Options
Immunogen Recombinant protein of human DSC1
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name DSC1 (DSC1 Antibody Abstract)
Background

Synonyms: Cadherin family member 1,CDHF1,Desmocollin1,Desmosomal glycoprotein 2/3,DG2/DG3,DSC 1,DSC1

Background: The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein.

Molecular Weight

Observed_MW: 105kDa

Calculated_MW: 93kDa/99kDa

Gene ID 1823
UniProt Q08554
Application Notes WB 1:500 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Desmocollin 1 (DSC1) antibody (ABIN6566762) Western blot analysis of extracts of various cell lines, using DSC1 antibody.