Synonyms: EI2BG,EIF 2B,eIF 2B GDP GTP exchange factor subunit gamma,eIF-2B GDP-GTP exchange factor subunit gamma,eIF2B-gamma,Eif2b3,EIF2Bgamma,Eukaryotic translation initiation factor 2B subunit 3 gamma,Eukaryotic translation initiation factor 2B,gamma,eukaryotic translation initiation factor 2B,subunit 3 gamma,58 kDa,OTTHUMP00000010262,OTTHUMP00000010263,Translation initiation factor eIF-2B subunit gamma
Background: The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.