Synonyms: 3'-5' exoribonuclease CSL4 homolog,CGI 108,CGI-108,CSL4,CSL4 exosomal core protein homolog,CSL4, S. cerevisiae, homolog of,Csl4p,EXOS1,Exosc1,Exosomal core protein CSL4,Exosome complex component csl4,Exosome component 1,hCsl4p,Homolog of yeast exosomal core protein CSL4,p13,RP11-452K12.9,SKI4,Ski4p
Background: This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. Alternative splicing of this gene results in multiple transcript variants.