Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4 (Psmd4) antibody

Details for Product No. ABIN6567005
Antigen
Reactivity
Human, Monkey, Mouse (Murine)
81
31
30
8
8
8
8
7
7
6
6
5
5
3
3
2
Host
Rabbit
72
9
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
5
4
4
4
4
4
1
1
1
1
1
1
Application
Western Blotting (WB)
79
45
29
7
4
3
2
1
1
1
1
1
Options
Immunogen Recombinant protein of human PSMD4
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name PSMD4 (Psmd4 Antibody Abstract)
Background

Synonyms: 26S protease subunit S5a,26S proteasome non ATPase regulatory subunit 4,26S proteasome non-ATPase regulatory subunit 4,26S proteasome regulatory subunit rpn10,26S proteasome regulatory subunit S5A,AF 1,AF,AF1,Angiocidin,Antisecretory factor 1,ASF,DS5a,MCB 1,MCB1,Multiubiquitin chain binding protein,Multiubiquitin chain-binding protein,OTTHUMP00000059963,Prosome macropain,Proteasome (prosome macropain) 26S subunit non ATPase 4,Proteasome 26S non ATPase subunit 4,Proteasome 26S subunit non ATPase 4,PSMD 4,Psmd4,PSMD4,pUB R5,pUBR5,Rpn 10,Rpn10,RPN10 homolog,S5A,S5a/antisecretory factor protein

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.

Molecular Weight

Observed_MW: 50kDa

Calculated_MW: 28kDa/40kDa

Gene ID 5710
UniProt P55036
Pathways Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
Application Notes WB 1:500 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4 (Psmd4) antibody (ABIN6567005) Western blot analysis of extracts of various cell lines, using PSMD4 antibody.