Synonyms: 28S ribosomal protein S13 mitochondrial,28S ribosomal protein S26 mitochondrial,C20orf193,dJ534B8.3,GI008,Mitochondrial ribosomal protein S26,MRP S13,MRP S26,MRPS13,NY BR 87,RPMS13,S13mt,S26mt,Serologically defined breast cancer antigen NY BR 87
Background: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75 % protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. This gene lies adjacent to and downstream of the gonadotropin-releasing hormone precursor gene.