SLC6A13 antibody (Solute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 13) (C-Term)

Catalog No. ABIN6658282

Product Details anti-SLC6A13 Antibody

Target: SLC6A13

Binding Specificity: C-Term

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC6A13 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Purification: Anti-GAT2 antibody is directed against rat GAT2 protein. GABA Transporter 2 antibodies are affinity purified from monospecific antiserum by immunoaffinity purification. Reactivity is expected from the following species based on 100% sequence homology: mouse.

Immunogen:

Immunogen: Anti-GABA Transporter 2 Antibody was produced in rabbit by repeated immunizations with synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.

Immunogen Type: Peptide

Isotype: IgG

Application Details

Application Notes:

Immunohistochemistry Dilution: 1:100-200

Application Note: Anti-GAT2 (Rabbit) Antibody is suitable for use in IHC. This antibody is not recommended for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. GAT2 antibody is specific for the approximately 82 kDa in size GABA Transporter 2 protein.

Western Blot Dilution: not recommended

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Target Details for SLC6A13

Target: SLC6A13

Alternative Name: GABA Transporter 2 (GAT2) (SLC6A13 Antibody Abstract)

Synonyms: GAT3, Gabt3, Gat2, GAT-2, GAT2, solute carrier family 6 (neurotransmitter transporter, GABA), member 13, solute carrier family 6 member 13, Slc6a13, SLC6A13

Background:

Synonyms: Sodium- and chloride-dependent GABA transporter 2, Solute carrier family 6 member 13

Background: GAT2 Antibody detects rat GAT2 protein. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-2 is found in a wide range of neuronal and non-neuronal cells including dendrites and axon terminals as well as epithelial cells and cells forming the pia and arachnoid complex. Anti-GAT2 Antibody is ideal for investigators involved in Neuroscience.

Gene Name: SLC6A13

Gene ID: 171163

NCBI Accession: NP_598307

UniProt: P31646