Clavesin 1 antibody (C-Term)

Catalog No. ABIN6658285

Supplier Product No.: 612-401-d17

Product Details anti-Clavesin 1 Antibody

Target: Clavesin 1 (CLVS1)

Binding Specificity: C-Term

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Clavesin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Supplier Product No.: 612-401-d17

Supplier: Rockland

Purpose: Clavesin Antibody

Cross-Reactivity (Details): Anti-Clavesin antibody is directed against rat Clavesin protein.

Purification: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-Clavesin Antibody was produced in rabbit by repeated immunizations with synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.

Isotype: IgG

Application Details

Application Notes:

ELISA_Dilution: 1:10,000

Western_Blot_Dilution: 1:1000

Other: ICC 1:50

Comment:

Anti-Clavesin antibody is tested for use in ELISA, Western Blotting and ICC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 35 kDa in size corresponding to clavesin protein doublet in Western Blots of rat brain lysate. Isoform-specific knock down in cultured hippocampal neurons indicates that the lower and upper bands are clavesin 1 and 2, respectively.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for Clavesin 1

Target: Clavesin 1 (CLVS1)

Alternative Name: Clavesin (CLVS1 Products)

Background:

Synonyms: Retinaldehyde-binding protein 1-like 1

Background: Clavesin antibody recognizes clavesin (clathrin vesicle associated Sec14 protein) which is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects. Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state. Anti-Clavesin antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: CLVS1/2

Gene ID: 366311

UniProt: A6JFQ6