SLC5A5 antibody (AA 525-618)

Catalog No. ABIN668751

Product Details anti-SLC5A5 Antibody

Target: SLC5A5 (Solute Carrier Family 5 (Sodium/iodide Cotransporter), Member 5 (SLC5A5))

Binding Specificity: AA 525-618

Reactivity: Human, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC5A5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Pig, Rat

Predicted Reactivity: Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse NIS

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-SLC5A5 antibody (ABIN668751)

Yang, Chen, Guo, Li, Tang, Xu, Sun, Ding, Jiang, Cui, Zheng, Duan: "Molecular Mechanisms of 2, 3', 4, 4', 5-Pentachlorobiphenyl-Induced Thyroid Dysfunction in FRTL-5 Cells." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120133, (2015) (PubMed).

Guo, Yang, Chen, Li, Tang, Cheng, Xie, Liu, Ding, Cui, Zheng, Duan: "Molecular mechanisms of human thyrocyte dysfunction induced by low concentrations of polychlorinated biphenyl 118 through the Akt/FoxO3a/NIS pathway." in: Journal of applied toxicology : JAT, Vol. 35, Issue 9, pp. 992-8, (2015) (PubMed).

Yao, Pan, Li, Xu, Lin, Wang, Wang: "Effect of sodium/iodide symporter (NIS)-mediated radioiodine therapy on estrogen receptor-negative breast cancer." in: Oncology reports, Vol. 34, Issue 1, pp. 59-66, (2015) (PubMed).

Target Details for SLC5A5

Target: SLC5A5 (Solute Carrier Family 5 (Sodium/iodide Cotransporter), Member 5 (SLC5A5))

Alternative Name: NIS (SLC5A5 Products)

Background:

Synonyms: Na+/I- cotransporter, Na+/I- symporter, Na+/I- cotransporter, Na+/I- symporter, Na+/I- cotransporter, Na+/I-symporter, NIS, SC5A5_HUMAN, SLC5A5, sodium iodide symporter, Sodium-iodide symporter, Sodium/iodide cotransporter, Solute carrier family 5 sodium iodide symporter member 5, Solute carrier family 5, Solute carrier family 5 member 5.

Background: catalyzes Na+/I- symporter activity plays a role in iodide transport and thyroid hormone generation.Human Sodium Iodide Symporter (hNIS) is responsible for iodide concentrating ability within thyroid follicular cells. It is a membrane bound glycoprotein with 13 membrane spanning domains and 14 extramembranous domains. It may represent an autoantigen in thyroid.

Gene ID: 114479

UniProt: Q99PN0