Nuclear Pore Complex antibody

Details for Product No. ABIN6699198
Antigen
Reactivity
Yeast (Saccharomyces cerevisiae)
5
3
3
2
1
1
Host
Mouse
6
Clonality (Clone)
Monoclonal ()
Application
Fluorescence Microscopy (FM)
3
3
2
2
1
Options
Immunogen

Immunogen: Anti-Nuclear Pore Complex Antibody (Monoclonal) was produced by repeated immunizations with yeast nuclear preparations.

Immunogen Type: Native Protein
Clone 39C7
Isotype IgG
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification Anti-Nuclear Pore Complex antibody is directed against Nuclear Pore Complex proteins. The antibody is protein G purified from concentrated clarified cell culture supernate. This antibody is directed against yeast NPC protein. Reactivity is expected from human, mouse and rat.
Antigen
Background

Synonyms: mouse anti-Nuclear Pore Complex Antibody, NPC, NUP62, NUP, NUP133

Background: Nuclear Pore Complex Antibodydetects Nuclear Pore Complex proteins. The nuclear pore complex (NPC) is a very large structure made up of at least 50 different proteins that span the double membrane of the nuclear envelope functioning as a gateway for macromolecular traffic between the cytoplasm and the nucleus. Discrete nuclear pore complex proteins or nucleoporins such as NUP98, NUP180 and p62 have been implicated in autoimmune disease and cancer. Patients with primary biliary cirrhosis (PBC) frequently produce autoantibodies against p62 and NUP180 while NUP98 translocations have been found in patients with acute myelogenous leukemia (AML). Anti-Nuclear Pore Complex Antibody is ideal for investigators involved in Cancer and Immunology Research.

Gene Name: Nuclear stain of multiple gene products including Nup62, Nup133
Application Notes

Application Note: Anti-Nuclear Pore Complex Antibody is suitable for use in IF. Specific conditions for reactivity should be optimized by the end user

IF Microscopy Dilution: 1:50-100
Restrictions For Research Use only
Format Liquid
Buffer

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
Supplier Images
Image no. 1 for anti-Nuclear Pore Complex antibody (ABIN6699198) Immunostaining of Anti-Nuclear Pore Complex (Mouse) Antibody - 200-301-D98 Immunofluo...
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