IL17A antibody (Interleukin 17A) (APC)

Details for Product anti-IL17A Antibody No. ABIN6728586
Target
Reactivity
Mouse
121
49
23
3
3
3
3
1
1
Host
Rat
79
36
19
19
3
1
Clonality (Clone)
Monoclonal ()
Conjugate
This IL17A antibody is conjugated to APC
24
18
12
8
7
5
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
101
98
39
16
13
11
10
7
6
5
4
3
3
1
1
1
1
1
1
1
1
1
Options
Clone TC11-18H10-1
Isotype IgG1, kappa
Target
Alternative Name IL-17A (IL17A Antibody Abstract)
Background

Synonyms: Interleukin-17A,IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8,CTLA8

Background: IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

Gene ID 16171
UniProt Q62386
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS with 0.05 % Proclin300, 1 % BSA
Preservative ProClin
Precaution of Use This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.