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CD40 antibody (CD40 Molecule, TNF Receptor Superfamily Member 5) (AA 29-107) Primary Antibody

CD40 Reactivity: Human Coat, ELISA, FACS, IHC, StM Host: Mouse Monoclonal C40-2383 unconjugated
Catalog No. ABIN6941187
$494.31
Plus shipping costs $45.00
100 μg ABIN6941187
100 μg ABIN6941187
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  • Target
    CD40
    Binding Specificity
    AA 29-107
    • 21
    • 20
    • 17
    • 15
    • 13
    • 12
    • 11
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Reactivity
    Human
    • 238
    • 114
    • 45
    • 13
    • 9
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Host
    Mouse
    • 153
    • 113
    • 50
    • 5
    • 1
    • 1
    Clonality
    Monoclonal
    • 208
    • 112
    • 1
    Conjugate
    This CD40 antibody is un-conjugated
    • 154
    • 30
    • 29
    • 22
    • 13
    • 7
    • 6
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Coating (Coat), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Staining Methods (StM)
    • 187
    • 107
    • 77
    • 63
    • 48
    • 37
    • 27
    • 22
    • 21
    • 13
    • 12
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Purification
    Purified by Protein A/G
    Immunogen
    Recombinant fragment of human CD40 protein (around aa 29-107) (exact sequence is proprietary)
    Clone
    C40-2383
    Isotype
    IgG2b kappa
  • Application Notes

    Positive Control: U2OS, L-428 cells. Tonsil, Spleen or Thymus.

    Known Application: ELISA (For coating, order antibody without BSA),Flow Cytometry (1-2 μg/million cells),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    CD40
    Alternative Name
    CD40 (CD40 Antibody Abstract)
    Synonyms
    Bp50, CDW40, TNFRSF5, p50, AI326936, GP39, HIGM1, IGM, IMD3, T-BAM, TRAP, Tnfrsf5, TNFSF5, CD40 molecule, CD40 antigen, CD40, Cd40
    Background
    CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs.
    Molecular Weight
    43kDa
    Gene ID
    958
    UniProt
    P25942
    Pathways
    NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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