DNASE1L2 antibody (AA 201-299) (AbBy Fluor® 594)

Catalog No. ABIN6943062

Product Details anti-DNASE1L2 Antibody (AbBy Fluor® 594)

Target: DNASE1L2 (Deoxyribonuclease I-Like 2 (DNASE1L2))

Binding Specificity: AA 201-299

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNASE1L2 antibody is conjugated to AbBy Fluor® 594

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DNASE1L2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DNASE1L2

Target: DNASE1L2 (Deoxyribonuclease I-Like 2 (DNASE1L2))

Alternative Name: DNASE1L2 (DNASE1L2 Products)

Background:

Synonyms: Deoxyribonuclease I-like 2, Deoxyribonuclease-1-like 2, DNase I homolog protein DHP1, DNase I-like 2, Dnase1l2, DNSL2_HUMAN.

Background: DNASE1L2 is a 299 amino acid secreted protein that is expressed in brain tissue and shares sequence similarity with DNase I, suggesting a possibly role in DNA hydrolysis. The gene encoding DNASE1L2 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3 % of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.

Gene ID: 1775

UniProt: Q92874