JNK1/JNK2/JNK3 antibody

Catalog No. ABIN6943853

Product Details anti-JNK1/JNK2/JNK3 Antibody

Target: JNK1/JNK2/JNK3

Reactivity: Mouse, Rat, Human, Monkey, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Monoclonal

Conjugate: This JNK1/JNK2/JNK3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))

Cross-Reactivity: Human, Monkey, Mouse, Rat, Zebrafish (Danio rerio)

Purification: Purified by Protein A.

Immunogen: Human JNK1+JNK2+JNK3 between 1 to 400 amino acids

Clone: 3G7

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for JNK1/JNK2/JNK3

Target: JNK1/JNK2/JNK3

Alternative Name: JNK1+JNK2+JNK3 (JNK1/JNK2/JNK3 Products)

Background:

Synonyms: C Jun kinase 2, c Jun N terminal kinase 1, c Jun N terminal kinase 2, c Jun N terminal kinase 3, c-Jun N-terminal kinase 1, JNK 46, JNK 55, JNK, JNK-46, JNK1, JNK1A2, JNK2, JNK21B1/2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, JNK3 alpha protein kinase, JNK3, JNK3A, Jun kinase, JUN N terminal kinase, MAP kinase 10, MAP kinase 8, MAP kinase 9, MAP kinase p49 3F12, MAPK 10, MAPK 8, MAPK 9, MAPK10, mapk8, MAPK9, Mitogen activated protein kinase 10, Mitogen activated protein kinase 8, Mitogen activated protein kinase 8 isoformJNK1 alpha1, Mitogen activated protein kinase 8 isoform JNK1 beta2, Mitogen activated protein kinase 9, Mitogen-activated protein kinase 8, MK08_HUMAN, p493F12, p54a, p54aSAPK, p54bSAPK, PRKM10, PRKM8, PRKM9, SAPK, SAPK(beta), SAPK1, SAPK1a, SAPK1b, SAPK1c, Stress activated protein kinase 1, Stress activated protein kinase1a, Stress activated protein kinase 1b, Stress activated protein kinase 1c, Stress activated protein kinase beta, Stress activated protein kinase JNK1, Stressactivated protein kinase JNK2, Stress activated protein kinase JNK3, Stressactivated protein kinase 1c, Stress-activated protein kinase JNK1,

Background: c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1a1,JNK1b1, JNK2a1, JNK2b1, and JNK3a1, which represent the p46 isoforms, and JNK1a2, JNK1b2, JNK2a2, JNK2b2, and JNK3b2, which represent the p54 isoforms.JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83 % amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun, and other signaling kinases, including MEKK1 and p38.

UniProt: P45983, P45984, P53779