NR1H3 antibody
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- Target See all NR1H3 Antibodies
- NR1H3 (Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- This NR1H3 antibody is un-conjugated
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- C terminal Human LXR alpha
- Clone
- 4A8
- Isotype
- IgG
- Top Product
- Discover our top product NR1H3 Primary Antibody
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- Application Notes
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- NR1H3 (Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))
- Alternative Name
- NR1H3 (NR1H3 Products)
- Synonyms
- NR1H3 antibody, LXR-a antibody, LXRA antibody, RLD-1 antibody, AU018371 antibody, LXR antibody, RLD1 antibody, Unr1 antibody, LXRalpha antibody, LXR-alpha antibody, im:7141239 antibody, wu:fd59b01 antibody, zgc:113339 antibody, zgc:158542 antibody, nuclear receptor subfamily 1 group H member 3 antibody, nuclear receptor subfamily 1, group H, member 3 antibody, NR1H3 antibody, nr1h3 antibody, Nr1h3 antibody
- Background
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Synonyms: Oxysterols receptor LXR-alpha, LXR alpha, Liver X receptor alpha, Nuclear receptor subfamily 1 group H member 3, NR1H3, LXRA, RLD-1.
Background: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism.
- Gene ID
- 10062
- UniProt
- Q13133
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Nuclear Hormone Receptor Binding, Cellular Response to Molecule of Bacterial Origin, Hepatitis C
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