Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) antibody

Details for Product No. ABIN6944317
Target
Reactivity
Human, Mouse, Rat
89
47
45
9
7
7
6
5
5
4
3
3
3
2
2
2
1
1
1
Host
Rabbit
80
12
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
7
5
4
2
2
2
2
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
75
39
17
13
7
6
5
5
2
2
2
2
1
1
1
Options
Immunogen C terminal Human LXR alpha
Clone 4A8
Isotype IgG
Purification Purified by Protein A.
Target
Alternative Name NR1H3 (NR1H3 Antibody Abstract)
Background

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism.

Subcellular location: Nucleus


Synonyms: Oxysterols receptor LXR-alpha, LXR alpha, Liver X receptor alpha, Nuclear receptor subfamily 1 group H member 3, NR1H3, LXRA, RLD-1.
Gene ID 10062
UniProt Q13133
Pathways Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Nuclear Hormone Receptor Binding, Cellular Response to Molecule of Bacterial Origin, Hepatitis C
Application Notes WB(1:500-1000), FCM(1:50-10), IHC-P(1:50-200), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months