ORC2 antibody

Details for Product No. ABIN6944371
Target
Reactivity
Human
50
5
5
3
2
1
1
1
1
1
Host
Mouse
40
8
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
2
2
2
2
2
1
1
1
1
1
1
Application
Western Blotting (WB)
45
23
7
7
6
4
3
1
1
1
Options
Immunogen Monoclonal antibody raised in mouse against human ORC2, using two recombinant proteins containing the N-terminal and C-terminal part of the protein, respectively
Clone 5C3
Isotype IgG1
Purification Protein G purified monoclonal antibody in PBS containing 0.05% azide.
Target
Background

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.


Synonyms: ORC2L, Origin recognition complex subunit 2, ORC2
Gene ID 4999
UniProt Q13416
Application Notes WB(1:300-1000)
Restrictions For Research Use only
Concentration 0.6 μg/μL
Storage -20 °C
Storage Comment Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles