ARPC5 antibody

Catalog No. ABIN6944379

Product Details anti-ARPC5 Antibody

Target: ARPC5 (Actin Related Protein 2/3 Complex, Subunit 5, 16kDa (ARPC5))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ARPC5 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Recombinant human p16 ARC around N-terminus

Clone: 8D8

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC()

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ARPC5

Target: ARPC5 (Actin Related Protein 2/3 Complex, Subunit 5, 16kDa (ARPC5))

Alternative Name: p16 ARC (ARPC5 Products)

Synonyms: arc16 antibody, p16-arc antibody, ARPC5 antibody, APOBEC4 antibody, ARC16 antibody, dJ127C7.3 antibody, p16-Arc antibody, MGC86407 antibody, 5830443F10Rik antibody, arpc5 antibody, fb09c07 antibody, fb12b05 antibody, fc56c07 antibody, wu:fb09c07 antibody, wu:fb12b05 antibody, wu:fc56c07 antibody, actin related protein 2/3 complex subunit 5 antibody, actin related protein 2/3 complex subunit 5 L homeolog antibody, actin related protein 2/3 complex, subunit 5 antibody, actin related protein 2/3 complex, subunit 5B antibody, actin related protein 2/3 complex, subunit 5A antibody, ARPC5 antibody, arpc5 antibody, arpc5.L antibody, Arpc5 antibody, arpc5b antibody, arpc5a antibody

Background:

Synonyms: Actin-related protein 2/3 complex subunit 5, Arp2/3 complex 16 kDa subunit, p16-ARC, ARPC5

Background: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).

Gene ID: 10092

UniProt: O15511

Pathways: RTK Signaling, Regulation of Actin Filament Polymerization