pan Keratin (panKRT) (AA 390-420) antibody (Alexa Fluor 750)

Details for Product No. ABIN6944413
Target
Binding Specificity
AA 390-420
15
15
15
10
7
1
1
1
Reactivity
Human, Mouse, Rat
193
137
134
63
55
39
39
38
37
22
21
21
21
7
1
1
1
1
1
Host
Rabbit
103
98
2
Clonality
Polyclonal
Conjugate
Alexa Fluor 750
10
7
7
6
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
109
95
92
54
53
50
33
16
14
12
11
3
2
1
1
Options
Immunogen KLH conjugated synthetic peptide derived from human cytokeratin 16
Isotype IgG
Purification Purified by Protein A.
Target
Alternative Name Pan Cytokeratin/ p-CK
Background

Cytokeratins, a group comprising at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratins 1, 4, 5, 6, and 8 are members of the type II neutral to basic subfamily. Antibody to cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. Anti Pan Cytokeratin (mixture) is a broadly reactive reagent, which recognizes epitopes present in most human epithelial tissues. It facilitates typing of normal, metaplastic and neoplastic cells. Synergy between the various components results in staining amplification. This enables identification of cells, which would otherwise be stained only marginally. The mixture may aid in the discrimination of carcinomas and nonepithelial tumors such as sarcomas, lymphomas and neural tumors. It is also useful in detecting micrometastases in lymph nodes, bone marrow and other tissues and for determining the origin of poorly differentiated tumors. There are two types of cytokeratins the acidic type I cytokeratins and the basic or neutral type II cytokeratins. Cytokeratins are usually found in pairs comprising a type I cytokeratin and a type II cytokeratin. Usually the type II cytokeratins are 8kD larger than their type I counterparts.


Synonyms: pan-cytokeratin, pan-CK, pan CK, P-CK, wide spectrum Cytokeratin, Cytokeratins, [cytokeratins 13, 14, 15, 16, 17, 19, 20, 24].
Application Notes IF(IHC-P)(1:50-200)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Expiry Date 12 months