The PAX5 gene is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis.
Synonyms: B cell lineage specic activator, B cell lineage specic activator protein, B cell specic activator protein, B cell specic transcription factor, B-cell-specic transcription factor, BSAP, EBB-1, KLP, Paired box 5, Paired box gene 5 B cell lineage specic activator protein, Paired box gene 5 B cell lineage specic activator, Paired box gene 5, Paired box homeotic gene 5, Paired box protein Pax 5, Paired box protein Pax-5, Paired domain gene 5, PAX 5, PAX5, PAX5_HUMAN, Transcription factor PAX 5.