PEX5 antibody (Peroxisomal Biogenesis Factor 5) (AA 70-120) (HRP)

Details for Product anti-PEX5 Antibody No. ABIN6944503
Target
Binding Specificity
AA 70-120
14
4
3
2
2
1
1
1
1
1
Reactivity
Human, Mouse, Rat
47
34
32
5
4
4
3
3
2
2
1
Host
Rabbit
42
4
1
Clonality
Polyclonal
Conjugate
This PEX5 antibody is conjugated to HRP
3
2
2
2
2
2
2
2
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
25
13
11
9
8
3
3
1
1
Options
Immunogen KLH conjugated synthetic peptide derived from human PEX5
Isotype IgG
Purification Purified by Protein A.
Target
Alternative Name PEX5 (PEX5 Antibody Abstract)
Background

The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]


Synonyms: FLJ50634, FLJ50721, FLJ51948, Peroxin 5, Peroxin-5, Peroxisomal biogenesis factor 5, Peroxisomal C terminal targeting signal import receptor, Peroxisomal C-terminal targeting signal import receptor, Peroxisomal targeting signal 1 receptor, Peroxisome receptor 1, pex5, PEX5_HUMAN, PTS1 BP, PTS1 receptor, PTS1-BP, PTS1R, PXR1.
Gene ID 5830
UniProt P50542
Pathways Monocarboxylic Acid Catabolic Process
Application Notes IHC-P(1:200-400)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Preservative Gentamicin sulfate
Precaution of Use This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Expiry Date 12 months