Phosphoinositide 3 Kinase, p85 alpha/gamma (PI3K p85a/g) (pTyr467) antibody (PE)

Details for Product No. ABIN6944546
Antigen
Epitope
pTyr467
22
19
15
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
27
27
27
4
1
Host
Rabbit
27
Clonality
Polyclonal
Conjugate
PE
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
13
13
7
6
4
4
3
3
2
Options
Immunogen KLH conjugated synthetic phosphopeptide derived from human PI3K around the phosphorylation site of p85 alphaTyr467
Isotype IgG
Purification Purified by Protein A.
Antigen
Alternative Name PI3 kinase p85 alpha , gamma
Background

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p11 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.

Subcellular location: Cytoplasm


Synonyms: p85, AGM7, GRB1, IMD36, p85-ALPHA, Phosphatidylinositol 3-kinase regulatory subunit alpha, PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, PI3-kinase subunit p85-alpha, PtdIns-3-kinase regulatory subunit p85-alpha, PIK3R1
Gene ID 5295
UniProt P27986
Application Notes FCM(1:20-100)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Expiry Date 12 months
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