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SARS-CoV-2 Nucleocapsid antibody (SARS-CoV-2 N) (AA 1-419) (HRP) Primary Antibody

SARS-CoV-2 N Reactivity: SARS Coronavirus-2 (SARS-CoV-2) ELISA Host: Human Monoclonal 1A6
Catalog No. ABIN6953157
$385.00
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 11 to 14 Business Days
  • Target
    Antibody Type
    Recombinant Antibody
    Binding Specificity
    AA 1-419
    Reactivity
    SARS Coronavirus-2 (SARS-CoV-2)
    Host
    Human
    Clonality
    Monoclonal
    Conjugate
    This SARS-CoV-2 Nucleocapsid antibody is conjugated to HRP
    Application
    ELISA
    Characteristics
    Recombinant anti-SARS-CoV-2 Nucleoprotein Mouse ScFv is expressed from 293 cells (HEK293) with a human IgG1 Fc tag on C-terminal.
    Mouse scFv fusion with human IgG1 Fc
    Purification
    Affinity-chromatography
    Immunogen
    Recombinant Human Novel Coronavirus Nucleoprotein (N) (1-419aa)
    Clone
    1A6
    Isotype
    IgG1
    Fragment
    scFv fragment
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    50 % Glycerol, 0.01M PBS, pH 7.4, 0.03 % Proclin 300
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze
  • Target
    Alternative Name
    SARS-CoV-2 Nucleocapsid Protein
    Background
    Nucleoprotein packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. It plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Coronavirus nucleoproteins are phosphoproteins, and are encoded near the 3' end of the genome. N possesses two RNA-binding domains: an N-terminal domain with adjacent S/R-rich motif and the C-terminal 209 amino acids. N protein is invovled in coronavirus infection with many ways: the C-terminal domain (CTD) of N is important for binding the genomic RNA packaging signal leading to selective genome incorporation, the N3 domain interacts with the endodomain of M to form virions, and the serine-arginine repeat region of N (SR) interacts with the first ubiquitin-like domain of nsp3 in a critical early replication step. Moreover, it has also been demonstrated that N can oligomerize through interactions in the CTD, bind viral RNA through the N-terminal domain, unwind double-stranded nucleic acid in the manner of an RNA chaperone, and pack in a helix through the N-terminal domain, though none of these other functions has yet been demonstrated to be important for infection.
    UniProt
    P0DTC9
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