FNDC3B antibody

Catalog No. ABIN7252033

Product Details anti-FNDC3B Antibody

Target: FNDC3B (Fibronectin Type III Domain Containing 3B (FNDC3B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FNDC3B antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Full length fusion protein

Isotype: IgG

Application Details

Application Notes: IHC 1:30-1:150, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.8 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FNDC3B

Target: FNDC3B (Fibronectin Type III Domain Containing 3B (FNDC3B))

Alternative Name: FNDC3B (FNDC3B Products)

Synonyms: FAD104 antibody, PRO4979 antibody, YVTM2421 antibody, 1600019O04Rik antibody, AW550168 antibody, Fad104 antibody, mKIAA4164 antibody, RGD1311673 antibody, FNDC3B antibody, DKFZp469D136 antibody, fibronectin type III domain containing 3B antibody, FNDC3B antibody, Fndc3b antibody, fndc3b antibody

Background: Adipogenesis, the process of transforming pre-adipocytes into mature fat cells, is of particular interest due to the role adipocytes play in obesity and type II diabetes. Adipocytes have been shown to affect a variety of functions, including hemostasis, angiogenesis and energy balance, by secreting hormones and bioactive peptides. The FNDC3B protein, also designated FAD104 (factor for adipocyte differentiation 104) or HCV NS5A-binding protein 37, is expressed during early adipogenesis. Belonging to the FNDC3 family of proteins, FNDC3B is a 1,204 amino acid protein that contains nine fibronectin type-III domains. FNDC3B-deficient mice die within one day of birth, suggesting that FNDC3B is crucial for postpartum survival. Mouse embryonic fibroblasts (MEFs) with loss of FNDC3B function displayed a reduction in stress fiber formation, indicating a role for FNDC3B in cell proliferation, adhesion, spreading and migration.

UniProt: Q53EP0

Pathways: Positive Regulation of fat Cell Differentiation