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PTTG1 antibody

PTTG1 Reactivity: Human, Mouse, Rat WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7264333
  • Target See all PTTG1 Antibodies
    PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))
    Reactivity
    • 46
    • 11
    • 10
    • 1
    Human, Mouse, Rat
    Host
    • 35
    • 11
    • 1
    Rabbit
    Clonality
    • 29
    • 18
    Polyclonal
    Conjugate
    • 29
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This PTTG1 antibody is un-conjugated
    Application
    • 22
    • 18
    • 11
    • 9
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human PTTG1 (NP_001269311.1).
    Isotype
    IgG
    Top Product
    Discover our top product PTTG1 Primary Antibody
  • Application Notes
    WB 1:500-1:2000 IHC 1:100-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))
    Alternative Name
    PTTG1 (PTTG1 Products)
    Synonyms
    EAP1 antibody, HPTTG antibody, PTTG antibody, TUTR1 antibody, PTTG1 antibody, securin antibody, AW555095 antibody, C87862 antibody, Pttg antibody, Pttg3 antibody, Securin antibody, Protein Cut2 antibody, pituitary tumor-transforming 1 antibody, pituitary tumor-transforming gene 1 antibody, securin, sister chromatid separation inhibitor antibody, PTTG1 antibody, Pttg1 antibody, cut2 antibody
    Background
    The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene.
    Molecular Weight

    Observed_MW: 24 kDa

    Calculated_MW: 22 kDa

    Gene ID
    9232
    UniProt
    O95997
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