TCR alpha/beta antibody
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- Target See all TCR alpha/beta products
- TCR alpha/beta (T Cell Receptor alpha/beta (TCR alpha/beta))
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Reactivity
- Rat, Non-Human Primate
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This TCR alpha/beta antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func), Immunocytochemistry (ICC)
- Specificity
- The mouse monoclonal R73 recognizes an extracellular epitope TCR alpha/beta, the dominant subtype of T cell receptor expressed in peripheral blood.
- Purification
- Purified by protein-A affinity chromatography.
- Endotoxin Level
- Low Endotoxin
- Immunogen
- Rat T blasts and erythrocytes
- Clone
- R73
- Isotype
- IgG1 kappa
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- Application Notes
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Flow cytometry: Recommended dilution: 1-4 μg/mL.
Functional application: In vitro activation and in vivo depletion of alpha/beta TCR T cells. - Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4
- Preservative
- Azide free
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
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- Target
- TCR alpha/beta (T Cell Receptor alpha/beta (TCR alpha/beta))
- Alternative Name
- TCR alpha/beta (TCR alpha/beta Products)
- Background
- The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.,TCRA/B
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