KCNQ5 antibody (Intracellular)

Catalog No. ABIN7043507

Product Details anti-KCNQ5 Antibody

Target: KCNQ5 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 5 (KCNQ5))

Binding Specificity: AA 856-869, Intracellular

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNQ5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Purpose: A Rabbit Polyclonal Antibody to KCNQ5 (KV7.5) Channel

Specificity: Intracellular, C-terminus

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Human,rat - identical

Characteristics: Anti-KCNQ5 Antibody (ABIN7043507, ABIN7045050 and ABIN7045051)) is a highly specific antibody directed against an epitope of the mouse KV7.5 channel. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize KCNQ5 from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)RGSQDFYPKWRESK, corresponding to amino acid residues 856-869 of mouse KCNQ5

Isotype: IgG

Application Details

Application Notes:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100

Application Dilutions Western blot wb: 1:200

Comment:

Cited Application: IHC|ICC

Negative Control: BLP-PC155

Blocking Peptide: BLP-PC155

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Storage: 4 °C,-20 °C

Storage Comment:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Details for KCNQ5

Target: KCNQ5 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 5 (KCNQ5))

Alternative Name: KCNQ5 (KCNQ5 Products)

Background: KV7.5, Potassium voltage-gated channel subfamily KQT member 5, KQT-like 5, KvLQT5,KCNQ genes encode members of the KV7 K+ channels. Structurally, the KCNQ family belongs to the six transmembrane domain category of K+ channels. Five members belong to this family (KCNQ1-KCNQ5) of which KCNQ2 to KCNQ5 are expressed in the nervous system1-3. KCNQ5 is also expressed in visceral smooth muscle4 and skeletal muscle5.These channels form subunits of the low threshold voltage gated K+ channel. KCNQ2 and KCNQ3 mostly form heteromers to form the M current. KCNQ5 is known to contribute to this current1.

Alternative names: KCNQ5, KV7.5, Potassium voltage-gated channel subfamily KQT member 5, KQT-like 5, KVLQT5

Gene ID: 226922

NCBI Accession: NM_019842

UniProt: Q9JK45