TRPC2 antibody (Intracellular)
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- Target See all TRPC2 Antibodies
- TRPC2 (Transient Receptor Potential Cation Channel, Subfamily C, Member 2 (TRPC2))
- Binding Specificity
- AA 12-24, Intracellular
- Reactivity
- Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TRPC2 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purpose
- A Rabbit Polyclonal Antibody to TRPC2 Channel
- Specificity
- Intracellular, N-terminus
- Cross-Reactivity
- Mouse, Rat
- Predicted Reactivity
- Rat - 12,13 amino acid residues identical
- Characteristics
- Anti-TRPC2 Antibody (ABIN7043817, ABIN7043982 and ABIN7043983) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot analysis. It has been designed to recognize TRPC2 from rat and mouse samples.
- Purification
- Affinity purified on immobilized antigen.
- Immunogen
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KNRSGVRMFKDGD, corresponding to amino acid residues 12-24 of mouse TRPC2
- Isotype
- IgG
- Top Product
- Discover our top product TRPC2 Primary Antibody
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- Application Notes
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
- Comment
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Cited Application: IHC
Negative Control: (ABIN7237413)
Blocking Peptide: (ABIN7237413)
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- Concentration
- 1 mg/mL
- Buffer
- PBS pH 7.4
- Storage
- 4 °C,-20 °C
- Storage Comment
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Target
- TRPC2 (Transient Receptor Potential Cation Channel, Subfamily C, Member 2 (TRPC2))
- Alternative Name
- TRPC2 (TRPC2 Products)
- Background
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Short transient receptor potential channel 2, Transient receptor protein 2, TRP2, mTrp2,TRPC (transient receptor potential cation) channels are the closest mammalian homologs of Drosophila TRP and TRP-like channels. TRPCs are rather nonselective Ca2+ permeable cation channels and affect cell functions through their ability to mediate Ca2+ entry into cells and their action to collapse the plasma membrane potentials1.The mammalian genome codes for seven TRPCs of which TRPC2 is the largest with the most restricted pattern of expression and has several alternatively spliced variant2. Expressed in model cells, TRPC2 mediates both receptor- and store depletion-triggered Ca2+ 3. In human, TPRC2 is a pseudogene3.Physiological roles for TRPC2 have been studied in mature sperm and the vomeronasal sensory system. In sperm, TRPC2 is activated by the sperm's interaction with the oocyte's zona pellucida, leading to entry of Ca2+ and activation of the acrosome reaction4. In the vomeronasal sensory organ (VNO), TRPC2 was found to constitute the transduction channel activated through signaling cascade initiated by the interaction of pheromones with V1R and V2R G protein-coupled receptors on the dendrites of the sensory neurons5. TRPC2-deficient mice display abnormal mating behavior, consistent with a role for this channel in pheromone signaling6.
Alternative names: TRPC2, Short transient receptor potential channel 2, Transient receptor protein 2, TRP2, mTrp2 - Gene ID
- 22064
- NCBI Accession
- NR_002720
- UniProt
- Q9R244
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