APOBEC3D antibody (AA 250-371)

Catalog No. ABIN7150152

Product Details anti-APOBEC3D Antibody

Target: APOBEC3D (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3D (APOBEC3D))

Binding Specificity: AA 250-371

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APOBEC3D antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human DNA dC->dU-editing enzyme APOBEC-3D protein (250-371AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for APOBEC3D

Target: APOBEC3D (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3D (APOBEC3D))

Alternative Name: APOBEC3D (APOBEC3D Products)

Background:

Background: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.

Aliases: A3D antibody, ABC3D_HUMAN antibody, APOBEC3D antibody, APOBEC3DE antibody, APOBEC3E antibody, Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3D antibody, Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3E pseudogene antibody, ARP6 antibody, bK150C2.9 antibody, BK150C2.9 protein antibody, DNA dC >dU editing enzyme APOBEC 3D antibody, DNA dC->dU-editing enzyme APOBEC-3D antibody, hCG_41704 antibody, HCG41704, isoform CRA_b antibody, Probable DNA dC->dU-editing enzyme APOBEC-3D antibody

UniProt: Q96AK3