DNAJB6 antibody (AA 208-326) (HRP)

Catalog No. ABIN7150531

Product Details anti-DNAJB6 Antibody (HRP)

Target: DNAJB6 (DnaJ (Hsp40) Homolog, Subfamily B, Member 6 (DNAJB6))

Binding Specificity: AA 208-326

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNAJB6 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human DnaJ homolog subfamily B member 6 protein (208-326AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DNAJB6

Target: DNAJB6 (DnaJ (Hsp40) Homolog, Subfamily B, Member 6 (DNAJB6))

Alternative Name: DNAJB6 (DNAJB6 Products)

Background:

Background: Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.

Aliases: DJ4 antibody, DnaJ antibody, DnaJ (Hsp40) homolog subfamily B member 6 antibody, DNAJ B6 antibody, DnaJ homolog subfamily B member 6 antibody, DnaJ like 2 protein antibody, DNAJB6 antibody, DNJB6_HUMAN antibody, Heat shock protein J2 antibody, HHDJ1 antibody, HSJ-2 antibody, HSJ2 antibody, LGMD1E antibody, MRJ antibody, MSJ-1 antibody, MSJ1 antibody

UniProt: O75190