DNAJC3 antibody (AA 277-496)

Catalog No. ABIN7150550

Product Details anti-DNAJC3 Antibody

Target: DNAJC3 (DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3))

Binding Specificity: AA 277-496

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNAJC3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human DnaJ homolog subfamily C member 3 protein (277-496AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DNAJC3

Target: DNAJC3 (DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3))

Alternative Name: DNAJC3 (DNAJC3 Products)

Background:

Background: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at \\\'Ser-52\\\' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.

Aliases: DnaJ (Hsp40) homolog subfamily C member 3 antibody, DnaJ homolog subfamily C member 3 antibody, DNAJC3 antibody, DNJC3_HUMAN antibody, double-stranded RNA-activated protein kinase inhibitor antibody, Endoplasmic reticulum DnaJ protein 6 antibody, ERdj6 antibody, HP58 antibody, Interferon induced, double stranded RNA activated protein kinase inhibitor antibody, Interferon-induced antibody, P58 antibody, p58 ipk antibody, P58IPK antibody, PRKRI antibody, Protein kinase inhibitor of 58 kDa antibody, Protein kinase inhibitor p58 antibody, Protein kinase interferon inducible double stranded RNA dependent inhibitor antibody

UniProt: Q13217

Pathways: ER-Nucleus Signaling